Watch the Stadium Rock: Technique 1 online guitar lesson by Robbie Calvo from RhythmCraft
Power chords are typically made up of the root and a perfect 5th but you can add in the 2nd (9th) and full triad chords can be used also. Quite honestly use your ears and if you think something works then go for it. The reason for playing power chords with simple voices is that with heavy distortion complex chords can start to sound mushy or undefined. I've used a combination of all the above variations to let you hear how that works in a studio setting. I also played the riff part accenting the single notes and you can hear that on the adding layers portion of this Stadium Rock course.
If you feel adventurous locate other ways of playing this progression on the guitar using just power chords or a combination approach like mine.
If you fancy jamming over this a great scale to use would be E minor pentatonic or the G major scale. In this case it would resolve to the VI so that would be E Aeolian. Don't get me started, this is a rhythm guitar course!