Watch the Mark Knopfler online guitar lesson by Jeff McErlain from Kings of Tone
Like many of the guitarists in this course Mark Knopfler's amp setup is pretty simple. He uses a tube amp and turns it up to where the amp provides its own natural distortion. This is the sound of rock and roll. Knopfler has gone through a number of different amps but during his early Dire Straits period I believe it was Fenders. Of late I know he has been using Komet and Reinhardt amps. As we can see the underlying thread here is a good tube amp turned up loud is a building block of good tone.