Watch the Funk-O-Rama - Solo online guitar lesson by Jeff Scheetz from Rock Solid
This solo has some chromatic lines, some wider interval skips, some one string sliding, and of course a bit of blues phrasing thrown in for good measure. I used a little bit cleaner sound for the solo on this one.
You don't want it to be too overdriven, but at the same time you want it to still rock, because in spite of the fact that the rhythm is clean the solo should still sing a bit. Play around with your effects a bit until you achieve a sound that feels comfortable and lends itself well to the music at the same time.