Watch the Funk Skanking online guitar lesson by Jennifer Batten from Rock Sauce for Rhythm Guitar
A lot of times what makes the most sense for a guitar part is to play funky single note riffs, especially if you’re playing with keyboards. There’s no need to double what the synth player is doing. I’ve been on gigs where I only played simple single note phrases for most of the night. The thing to focus on aside from your note choices is the feel. This is a very percussive technique so it’s very important to lock in with the bass and drums because you’re essentially in their turf.