Watch the Blues Blender online guitar lesson by Chris Buono from 50 Rock Guitar Licks You MUST Know

The real pudding in the blues-rock pie is the ability for the lick-meister (that's you) to smoothly combine major and minor sounds within one lick. Look no further than Eric Clapton's monumental solo in Cream's take on the Robert Johnson penned "Crossroads" from the trio's 1968 album, Wheels of Fire. With clever slurs of the 3rd, this lick hearkens back to the genius Slowhand cast down upon the world in that astral solo.

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