Watch the Third Base online guitar lesson by TrueFire from Play Blues Guitar 4: Rhythm Approaches
Third Base - Rhythm 40 is a video guitar lesson presented by Corey Congilio and is sourced from 50 Blues Rhythms You MUST Know.
I like this example a lot because it gives you the blues flavor without a bunch of 7th chords.
I'm primarily using major and minor thirds to achieve the shapes for this one. I'm playing one of my favorite inversions for the I chord. The chord is A/C# and this is a shape that you'll hear many rock players use.
We've been discussing chord tones a good bit in this course. A/C# is just a simple A triad. The notes are A, C#, and E. The C# is the lowest note in the chord. I use a simple D triad in bar 6. I play through the 5 chord with a riff and I finish it up with one of my favorite shapes for E7.
This could be used in a rhumba blues or a New Orleans-type of groove. Go for it.