Watch the Bmin Blues online guitar lesson by Larry Carlton from 335 Blues
Anyone who has played guitar in a trio setting knows it can leave you with a lot of elbow room to improvise and open your playing up. But it also leaves you with a lot of responsibility, since you have to outline the progression, take care of your rhythm chores, play the melody and pull off an exciting solo - often times simultaneously.
When I'm accompanying myself (or playing with just bass and drums) I find it very helpful to think about the listener's experience. Interjecting chord changes while soloing will keep the listeners comfortable with where you are in the song, so the solo isn't just floating around without a harmonic reference for the listener to connect with. So, often times you'll construct your solo with enough space to interject those chord changes and references.