Watch the Falling Up Solo Study online guitar lesson by Allen Hinds from Melodic Improv
This is a song of mine called "Falling Up". The chord changed here aren't heavy duty, and they're close enough to the tonal center of E minor where I can pretty much play E blues through the changes. I hear a lot of blues players go without playing every chord in a progression, but they have a good enough ear and understanding of the instrument to know where they shouldn't go. You can get away with just playing blues licks most of the time if you have a good sense of where things are going.