Watch the Alternate Picking: Level 2 online guitar lesson by Chris Buono from Guitar Gym: Alternate Picking Workouts

Workout #1 starts off with a pair of P4's a whole step apart that both ascend and descend and move down the neck chromatically. This sets up a situation where you're picking both on the outside and insides of the adjacent string pairs, but still keeping it pretty simple so you can concentrate on the both types of pivots. Be sure to "roll" your fret hand fingers as you play the 4ths so as to not let any notes ring into each other.

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