Watch the Bird Out online guitar lesson by Jeff McErlain from Essentials: Chord Tone Soloing
Here I start off by just messing with the BB's box idea - this is an essential fingering/idea that every guitar player should become familiar with. It's truly the basis of that sweet major blues sound that I love so much in BB and Peter Green. Check out John Mayer and Joe Bonamassa soloing over this one for a cool modern take on the traditional version, which they do so well!
Now once you have a handle on that (got a lifetime?), start adding in one new note at a time. That's the way to get it done; don't get overwhelmed, one note at a time is the key. Even if all you do in that week or practice session is get that one note into your playing, you have moved forward.