Watch the From Tiny To Junior: Solo 2 online guitar lesson by David Blacker from Swing Blues Survival Guide: Lead
Jazz players often weave long phrases through different chord changes, outlining the key chord tones as they happen. To play really good jump or west coast blues lead, you need to be able to do this. So the goal is to think like jazz players, but to remain rooted in blues phrasing.
This solo has some great long phrases that weave through the changes, especially the phrase that transitions from the I to the IV chord. It begins with a characteristic T-Bone chromatic riff, then pedals back and forth between the b5th and the 5th, walks up from 5th to 6th to 7th and then back down, and finally resolves so that it targets the dominant 7th of the IV chord just as the change happens. If you're just starting out playing through changes, don't think too much about it. The best way to approach it is to learn the lines, get them under your fingers, and then go back and analyze the chord tones. It takes awhile before this becomes second nature, but if you begin to recognize the key chord tones relative to each change, it will start to happen.