Watch the The Mixolydian Mode online guitar lesson by Jeff Beasley from Shred Ahead Blues Rock
The mixolydian mode is simply a major scale with a flat seven, melodically speaking. Harmonically speaking there are new implications as well. One noteworthy difference in the mixolydian mode is the fact that the five-chord is minor. A common example is the song Louie, Louie. In that old tune the one, four and a minor five chord are used for a very memorable progression.