Watch the Mississippi Blues 11 online guitar lesson by Tim Sparks from Post-Modern Fingerstyle Blues

Every time the 12-bar form comes back around, it's another opportunity to reinvent. The sixth features a melody riff harmonized in sixths over a boogie bass line, with both open and fretted strings at work. After an important note about hand positioning and posture, we're into some tasteful chord substitutions that liven up the standard blues progression - something that might be welcome to the listener's ear by the sixth or seventh time the progression comes around.