Watch the 12 AM: Lead 1 online guitar lesson by Andy Aledort from Jam Night Vol. 2
The first pair of sixths played over the D chord represents the major third, F#, and the high root note, D. As the following chord is B, I simply move the D up to D# to sound what is now F#, the fifth, and D#, the major third, of B. This fifth/third above combo is then applied to the following A and G chords. The initial solo lines over the verse emulate the vocal melody, as I stick with the E major pentatonic scale (E F# G# B C#). In bar 7 of the verse, I briefly reference the E minor pentatonic scale (E G A B D) to bring more of a blues feeling into the solo. I then commit to the blues approach over B and A with Johnny Winter-style lines based on the B blues scale (B D E F F# A) and the A blues scale (A C D Eb E G), respectively. On the return to the E-to-A progression, I combine a bit of a country approach - exemplified by oblique bends (on a two-note figure, one string is bent while another is unbent) - with the bluesy, melodic sound of E major pentatonic, and then wrap the solo up with a restatement of sliding sixths that directly reference the closing D and B chords.