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Watch the Home On The Grange: Lead 1 online guitar lesson by Andy Aledort from Jam Night Vol. 1

Billy Gibbon's immortal "La Grange" solo is highlighted by pinch or artificial harmonics, sounded by using a great deal of distortion combined with getting a bit of flesh (the side of the thumb) into the pick attack. I utilize that approach for this solo, moving the pick to different spots along the length of the string to sound different harmonics in the overtone series.