Watch the Pickin' My Blues online guitar lesson by John Hatcher from Fingerstyle Blues Roots
"Pickin' My Blues" is a ragtime based tune in C that is sure to build your fingerpicking chops. There's quite a lot going on with the alternating bass, constant chord changes and bright, syncopated melody. You'll hear similar chord progressions in Blind Boy Fuller's staple, "Truckin' My Blues Away" and even Robert Johnson's outlier tune, "They're Red Hot".
Have a listen and focus on the melody. Let the melody guide you through the chord changes and this one will fall in place much quicker.