Watch the No More Trouble online guitar lesson by Jeff McErlain from Blues Guitar Fakebook: Rhythm Vol. 2
Let's talk a little bit about guitar tone. What you've going in the original recording is basically the classic Les Paul into a Marshall half stack rock'n roll tone. Don't be fooled by the simplicity of that, it has all you really need right there, as we can see from Jimmy Page, Eric Clapton, Peter Green, and countless other classic guitar players.
Keeping your rig as simple as possible is something I subscribe to as well. I'm a fan of a pure guitar/amp tone with all the dynamics and tones coming from the player. I highly recommend this approach, or at least a minimal pedalboard. You always need a tuner!