Watch the Function Junction Rhythm online guitar lesson by Jeff Scheetz from Blues-Rock: Secret Sauce
The other thing about this song is that it has a bit of a change up in it. It goes from this busy funky thing to this open heavy chord riff. Reminds me of an Allman Brothers thing or a bit of a mutation of funk and blues rock.
Switch your soloing tactics when the rhythm of the song changes, but mix it up. The normal approach is to go heavy when the rhythm goes heavy, but try the opposite - get mellow when the rhythm gets rockin' and get rad when the rhythm cleans up. Always try the unusual - even if it doesn't work it will help stretch your idea development skills.