Watch the Ain't That Sweet online guitar lesson by Jeff McErlain from 50 Eclectic Blues Licks You MUST Know
As you can see, I like 6ths. A very cool interval that comfortably lends themselves to the blues.
This lick is in A mixolydian, when you feel comfortable with this one try plugging in into the blues using the IV and V chords by outlining each of those related mixolydian scales.
Sound hard? Not really, there is only one note difference between each scale. What IS hard work is knowing that fingerboard!