Watch the Chromatica online guitar lesson by Jeff McErlain from 50 Blues Rock Guitar Licks You MUST Know
Here is a classic lick that mixes both the major and minor blues scales. If you notice I play C, C#, D, Eb, and E in a row. This sounds great over a dom7 chord, but whatever you do, don't play this lick over a minor chord! Dom7 chords can accept more musical information much more easily than minor chords. We can play a b3 on a dom chord because it sounds cool and bluesy. But if we play a natural 3rd on a minor chord it sounds really bad. So be careful!