Watch the Comfortable One online guitar lesson by TrueFire from Blues Guitar Greatest Hits Vol. 3
Comfortable One is a video guitar lesson presented by Play in the Style of David Gilmour
The IV to I chord change is so simple yet so satisfying. The lead part is similarly simple and elegant. It has to be played in tune and in time in order to have any impact. This is where music is at its most fragile. You can absolutely mess this up, so don't - practice it.