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Watch the Playing on the E String online guitar lesson by David Hamburger from Blues Guitar For Beginners

The main riff to this twelve bar blues solo is a nod to "Baby Please Don't Go," the one-chord tune covered by Mance Lipscomb and Lightnin' Hopkins, John Lee Hooker and Muddy Waters, Ted Nugent, Aerosmith, Bob Dylan and John Lennon. A well-travelled song, indeed. Songs built around just one chord are sometimes called "vamp" tunes, from the jazz term for hanging out on one chord waiting for the action to start. Except on blues tunes like "Baby Please Don't Go," the vamp is the action.
>>Muddy Waters